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21.
陈孟奇 《电信工程技术与标准化》2018,(9)
近年,各类专线业务的“大带宽、低时延、快响应”诉求愈加明显,对传送网的承载能力提出更高的要求,特别是其中N*10G 业务需求规模逐年增加, 有必要研究一套标准化的承载模式来满足业务接入的需求,以实现对业务连接的网络承载模式标准化、快速化、智能化。 相似文献
22.
23.
Deploy Efficiency Driven k-Barrier Construction Scheme Based on Target Circle in Directional Sensor Network 下载免费PDF全文
Fan Xing-Gang Che Zhi-Cong Hu Feng-Dan Liu Tao Xu Jin-Shan Zhou Xiao-Long 《计算机科学技术学报》2020,35(3):647-664
Journal of Computer Science and Technology - With the increasing demand for security, building strong barrier coverage in directional sensor networks is important for effectively detecting... 相似文献
24.
放顶煤开采期间,上覆岩层受到矿压的影响,形成冒落带、裂隙带、弯曲下沉带,工作面采空区遗煤和围岩涌出的大量瓦斯飘浮在上方裂隙带区域,造成瓦斯聚集并向外涌出,形成了安全隐患,因此必须将该区域瓦斯抽出来;以往治理采空区瓦斯主要采用顶板裂隙高位钻场、顶板高抽巷等措施,但是这2种方法施工成本较高,且施工周期长,对生产接替影响较大。煤层顶板裂隙高位定向长钻孔安全高效抽采采用大功率钻机+定向钻进技术,在裂隙带施工控制整个回采范围的长钻孔,减少采空区和邻近层瓦斯向工作面空间的流动,真正实现了“以孔代巷”,既节省了成本,又缩短了工期,还提高了采空区瓦斯抽采的连续性、稳定性,减少了采空区瓦斯向外涌出,提升了瓦斯抽采效果,促进了煤矿安全高效发展。 相似文献
25.
Cecilia Arriagada Viviana A. Cavieres Charlotte Luchsinger Alexis E. Gonzlez Vanessa C. Muoz Jorge Cancino Patricia V. Burgos Gonzalo A. Mardones 《International journal of molecular sciences》2020,21(22)
Protein trafficking is altered when normal cells acquire a tumor phenotype. A key subcellular compartment in regulating protein trafficking is the Golgi apparatus, but its role in carcinogenesis is still not well defined. Golgi phosphoprotein 3 (GOLPH3), a peripheral membrane protein mostly localized at the trans-Golgi network, is overexpressed in several tumor types including glioblastoma multiforme (GBM), the most lethal primary brain tumor. Moreover, GOLPH3 is currently considered an oncoprotein, however its precise function in GBM is not fully understood. Here, we analyzed in T98G cells of GBM, which express high levels of epidermal growth factor receptor (EGFR), the effect of stable RNAi-mediated knockdown of GOLPH3. We found that silencing GOLPH3 caused a significant reduction in the proliferation of T98G cells and an unexpected increase in total EGFR levels, even at the cell surface, which was however less prone to ligand-induced autophosphorylation. Furthermore, silencing GOLPH3 decreased EGFR sialylation and fucosylation, which correlated with delayed ligand-induced EGFR downregulation and its accumulation at endo-lysosomal compartments. Finally, we found that EGF failed at promoting EGFR ubiquitylation when the levels of GOLPH3 were reduced. Altogether, our results show that GOLPH3 in T98G cells regulates the endocytic trafficking and activation of EGFR likely by affecting its extent of glycosylation and ubiquitylation. 相似文献
26.
选择Sasobit和Evotherm 3G两种温拌剂对温拌LDPE沥青混合料制备工艺和性能进行研究。首先,比较变温等体积法和等黏温度法两种方法,并确定两种温拌混合料的拌和及击实温度。在此基础上,分别采用车辙试验、低温弯曲试验、中点加载弯曲试验以及冻融劈裂试验评价70#、LDPE、Sasobit-LDPE以及3G-LDPE四种沥青混合料的高温性能、低温性能、疲劳性能和水稳定性。结果表明,两种温拌技术均是可行的,Sasobit和3G温拌技术可使施工温度降低20℃和15℃。与热拌LDPE沥青混合料相比,Sasobit温拌沥青混合料具有更好的高温性能和水稳定性,在高应力比条件下抗疲劳性能更好,低温性能虽变差,但是优于70#沥青混合料;3G温拌沥青混合料的高温性能,低温性能以及水稳定性则与热拌LDPE沥青混合料各项性能较为接近,抗疲劳性能变差,但是优于70#沥青混合料。 相似文献
27.
《Planning》2018,(4):62-64
目的:检测抑郁症患者经舍曲林治疗6周前后外周血中IL-17等细胞炎症因子水平变化。方法:选取2015年9月-2017年8月本院抑郁症患者30例为试验组,另选同期健康查体者30例为健康对照组,检测两组治疗前后血清IL-6、TNF-α、IL-1β、IL-17表达水平并进行比较。结果:治疗前,健康对照组IL-6、TNF-α、IL-1β、IL-17的表达水平均低于试验组,比较差异均有统计学意义(P<0.05);治疗后,试验组血清IL-6、TNF-α、IL-1β、IL-17的表达水平均低于治疗前,比较差异均有统计学意义(P<0.05)。结论:抑郁症患者由分泌IL-17为主的细胞因子而造成机体免疫功能紊乱,舍曲林抗抑郁的同时降低抑郁症患者血清IL-6、TNF-α、IL-1β、IL-17水平。 相似文献
28.
Nina Kobal Tjaa Kraovec Maja utar Marija Volk Borut Peterlin Marko Hawlina Ana Fakin 《International journal of molecular sciences》2021,22(4)
Mutations in rhodopsin gene (RHO) are a frequent cause of retinitis pigmentosa (RP) and less often, congenital stationary night blindness (CSNB). Mutation p.G90D has previously been associated with CSNB based on the examination of one family. This study screened 60 patients. Out of these 60 patients, 32 were affected and a full characterization was conducted in 15 patients. We described the clinical characteristics of these 15 patients (12 male, median age 42 years, range 8–71) from three families including visual field (Campus Goldmann), fundus autofluorescence (FAF), optical coherence tomography (OCT) and electrophysiology. Phenotypes were classified into four categories: CSNB (N = 3, 20%) sector RP (N = 3, 20%), pericentral RP (N = 1, 6.7%) and classic RP (N = 8, 53.3% (8/15)). The phenotypes were not associated with family, sex or age (Kruskal–Wallis, p > 0.05), however, cystoid macular edema (CME) was observed only in one family. Among the subjects reporting nyctalopia, 69% (22/32) were male. The clinical characteristics of the largest p.G90D cohort so far showed a large frequency of progressive retinal degeneration with 53.3% developing RP, contrary to the previous report. 相似文献
29.
Zahra Maria Emma Turner Agnieshka Agasing Gaurav Kumar Robert C. Axtell 《International journal of molecular sciences》2021,22(6)
Pertussis toxin (PTX) is a required co-adjuvant for experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin antigen. However, PTX’s effects on EAE induced by the transfer of myelin-specific T helper cells is not known. Therefore, we investigated how PTX affects the Th17 transfer EAE model (Th17-EAE). We found that PTX significantly reduced Th17-EAE by inhibiting chemokine-receptor-dependent trafficking of Th17 cells. Strikingly, PTX also promoted the accumulation of B cells in the CNS, suggesting that PTX alters the disease toward a B-cell-dependent pathology. To determine the role of B cells, we compared the effects of PTX on Th17-EAE in wild-type (WT) and B-cell-deficient (µMT) mice. Without PTX treatment, disease severity was equivalent between WT and µMT mice. In contrast, with PTX treatment, the µMT mice had significantly less disease and a reduction in pathogenic Th17 cells in the CNS compared to the WT mice. In conclusion, this study shows that PTX inhibits the migration of pathogenic Th17 cells, while promoting the accumulation of pathogenic B cells in the CNS during Th17-EAE. These data provide useful methodological information for adoptive-transfer Th17-EAE and, furthermore, describe another important experimental system to study the pathogenic mechanisms of B cells in multiple sclerosis. 相似文献
30.
With the growing availability of hand-held cameras in recent years, more and more images and videos are taken at any time and any place. However, they usually suffer from undesirable blur due to camera shake or object motion in the scene. In recent years, a few modern video deblurring methods are proposed and achieve impressive performance. However, they are still not suitable for practical applications as high computational cost or using future information as input. To address the issues, we propose a sequentially one-to-one video deblurring network (SOON) which can deblur effectively without any future information. It transfers both spatial and temporal information to the next frame by utilizing the recurrent architecture. In addition, we design a novel Spatio-Temporal Attention module to nudge the network to focus on the meaningful and essential features in the past. Extensive experiments demonstrate that the proposed method outperforms the state-of-the-art deblurring methods, both quantitatively and qualitatively, on various challenging real-world deblurring datasets. Moreover, as our method deblurs in an online manner and is potentially real-time, it is more suitable for practical applications. 相似文献